I'm not a fan of Nip-Tuck (never actually watched it), but I am a big fan of TV shows or movies where actors play off their public image (see Neil Patrick Harris in Harold and Kumar or Stephen Collins on It's Always Sunny in Philadelphia).
So, it made me laugh when, on a preview for next week's Nip-Tuck, they promoted a guest-star appearance by Rosie O'Donnell going to the clinic for a procedure which will require the doctor's to sew her mouth shut.

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